We collected 216 Arabidopsis epigenomic datasets, including ChIP-seq, DNase-seq, ATAC-seq and DNA methylation data. A Hidden Markov Model was applied to aggregate or collapse the multi-dimensional matrices into a small number of chromatin states. We identified 36 chromatin states located in 290,553 segments across the whole genome and different chromatin states contained different epigenetic features.
After chromatin state partition, we employed self-organization mapping (SOM) to integrate, visualize, and mine diverse epigenomic datasets, including 1,350 units that contained different chromatin signatures.
State | Preferential epigenetics marks | Preferential location |
---|---|---|
State 1 | H3.3 | 3'UTR |
State 2 | H3.3, histone acetylation,H3K4me2,H2A.Z | CDS,3'UTR |
State 3 | H3K4me1,H3.3,H3.1 | CDS |
State 4 | H3K4me1,H3.3 | CDS,intron |
State 5 | H3K4me1,H3K36me3,H3.3,H3.1 | CDS |
State 6 | H3K4me1,H3K36me3 | intron |
State 7 | H3K4me1,H3K36me3,H3K4me2 | CDS,intron |
State 8 | H3K4me1,H3K4me2,H2A.Z | CDS |
State 9 | H3K4me1 | intron |
State 10 | H2A.Z | CDS,intron |
State 11 | H3K27me3,H2A.Z,H3K4me2 | CDS |
State 12 | H3K27me3,H2A.Z | Promoter,CDS,intron,intergenic |
State 13 | H3K27me3,H2A.Z | Promoter,intergenic |
State 14 | H3K27me3 | Promoter,intergenic |
State 15 | H3K27me3,accessible DNA | Promoter,intergenic |
State 16 | accessible DNA | Promoter,intergenic |
State 17 | accessible DNA | Promoter |
State 18 | accessible DNA | Promoter |
State 19 | accessible DNA | Promoter,snRNA |
State 20 | accessible DNA | Promoter |
State 21 | accessible DNA | Promoter |
State 22 | histone acetylation,H3K4me2 | coding gene,miRNA,snoRNA |
State 23 | accessible DNA,H3K36ac,H3K56ac,H4K16ac,H3K4me3 | Promoter,5'UTR |
State 24 | accessible DNA,histone acetylation,H3K4me3 | 5'UTR,snoRNA |
State 25 | histone acetylation,H3K4me3,H3K4me2,H2A.Z | intron |
State 26 | histone acetylation,H3K4me3,H3K4me2,H2A.Z | CDS |
State 27 | H3K4me2,histone acetylation,H3K4me3,H2A.Z | CDS |
State 28 | H3K4me3,H3K4me2,H2A.Z | intron |
State 29 | weak signal | intergenic |
State 30 | rare signal | intergenic |
State 31 | DNA methylation,H3K9me2,H3K27me3 | intergenic,miRNA |
State 32 | DNA methylation,H3K9me2 | intergenic,TE |
State 33 | H3K9me2,DNA methylation | TE |
State 34 | H3K9me2,DNA methylation,H3K27me1 | TE,miRNA |
State 35 | H3K9me2,DNA methylation,H2A.X | intergenic,pericentromere |
State 36 | CENH3,H3K9me2,DNA methylation,accessible DNA | rRNA,tRNA,centromere |
Segment counts of SOM map | Nucleotide counts of SOM map |